Microarray Expression Profiles of lncRNAs and mRNAs in Postoperative Cognitive Dysfunction.

ABSTRACT: Postoperative cognitive dysfunction (POCD) is serious disorder in the central nervous system common in aged patients after anesthesia. Although its clinical symptoms are well recognized, however, the molecular etiology of the POCD remains unrevealed. Similarly, neither gold standard molecular diagnosis nor effective treatment is available for POCD until the present. Therefore, we aimed to explore the molecular mechanism of this disorder through investigating lncRNAs and mRNAs associated with POCD human patients and investigate their underlying regulatory pathways. In this study, we recruited 200 patients requiring hip or knee replacement surgery. Their neurological functions were assessed at two time points, 1 day before the surgery and 30 days post-surgery. In parallel, serum samples were

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC6187303 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature