Visualization of oxidative injury in the mouse kidney using selective superoxide anion fluorescent probes.

ABSTRACT: Drug-induced acute kidney injury (AKI), caused by renal drug metabolism, has been regarded as a main problem in clinical pharmacology and practice. However, due to the lack of effective biomarkers and noninvasive real-time tools, the early diagnosis of drug-induced AKI is still a crucial challenge. The superoxide anion (O₂˙^-), the preliminary reactive oxidative species, is closely related to drug-induced AKI. In this paper, we reported two new mitochondria-targeted fluorescent probes for investigating AKI via mapping the fluctuation of O₂˙^- with high sensitivity and selectivity by the combination of rational design and a probe-screening approach. Small-molecule fluorescent probes (Naph-O₂˙^- and NIR-O_2</

SUBMITTER: Lv Y 

PROVIDER: S-EPMC6187691 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature