Extend, Pathomechanism and Clinical Consequences of Brain Volume Changes in Anorexia Nervosa.

ABSTRACT:

Introduction

Brain volume deficits of grey matter (GM) and white matter (WM) are often found in patients with anorexia nervosa (AN). However, until recently, little was known about the influencing factors of these brain volume alterations, nor their exact quantification and rehabilitation.

Methods

This review addresses these open questions and further explores what is now known about the underlying pathobiology and the clinical consequences including human studies as well as animal studies mimicking anorexia nervosa in rodents.

Results

GM was reduced by 3.7% in adults and 7.6% in adolescents with AN. WM was reduced on average 2.2% in adult patients and 3.2% in adolescents. Most volume deficits in adults are reversible after long-term recovery; for adolescents, data ar

SUBMITTER: Seitz J 

PROVIDER: S-EPMC6187749 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature