Biological significance and prognostic/predictive impact of complex karyotype in chronic lymphocytic leukemia.

ABSTRACT: The complex karyotype (CK) is an established negative prognostic marker in a number of haematological malignancies. After the introduction of effective mitogens, a growing body of evidence has suggested that the presence of 3 or more aberrations by conventional banding analysis (CBA) is associated with an unfavorable outcome in chronic lymphocytic leukemia (CLL). Thus, the importance of CBA was recognized by the 2018 guidelines of the International Workshop on CLL, which proposed the introduction of CBA in clinical trials to validate the value of karyotype aberrations. Indeed, a number of observational studies showed that cytogenetic aberrations and, particularly, the CK may have a negative independent impact on objective outcome measures (i.e. time to first treatment, progression free sur

SUBMITTER: Cavallari M 

PROVIDER: S-EPMC6188145 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature