Sera from patients with active pulmonary tuberculosis and their household contacts induce nuclear changes in neutrophils.

ABSTRACT:

Background

Resident alveolar macrophages, dendritic cells, and immigrating neutrophils (NEU) are the first cells to contact Mycobacterium tuberculosis in the lung. These cells, and additional lymphoid cells in the developing granuloma, release a series of components that may concentrate in the serum and affect disease progression.

Purpose

The aim of this study was to investigate the effect of the serum from tuberculosis (TB) patients and their household contacts (HHC) on the nuclear morphology of NEU.

Materials and methods

NEU from healthy (HLT) people were incubated with sera from patients with active pulmonary TB, their HHC, and unrelated people. Changes in the nuclear morphology of NEU were analyzed by light and electron microscopy.

Results

Sera from

SUBMITTER: Juarez-Ortega M 

PROVIDER: S-EPMC6188193 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature