Recurrent Amplification of the Heterochromatin Protein 1 (HP1) Gene Family across Diptera.

ABSTRACT: The heterochromatic genome compartment mediates strictly conserved cellular processes such as chromosome segregation, telomere integrity, and genome stability. Paradoxically, heterochromatic DNA sequence is wildly unconserved. Recent reports that many hybrid incompatibility genes encode heterochromatin proteins, together with the observation that interspecies hybrids suffer aberrant heterochromatin-dependent processes, suggest that heterochromatic DNA packaging requires species-specific innovations. Testing this model of coevolution between fast-evolving heterochromatic DNA and its packaging proteins begins with defining the latter. Here we describe many such candidates encoded by the Heterochromatin Protein 1 (HP1) gene family across Diptera, an insect Order that encompasses dramatic epis

SUBMITTER: Helleu Q 

PROVIDER: S-EPMC6188558 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature