Design of a cytocompatible hydrogel coating to modulate properties of ceramic-based scaffolds for bone repair.

ABSTRACT:

Introduction

Physical and mechanical properties of ceramic-based scaffolds can be modulated by introducing hydrogel coatings on their surface. For instance, hydrogels can be used as elastic layers to overcome the brittleness of synthetic ceramic materials or to control the delivery of essential osteogenic factors. In this work, we aimed to achieve both goals by fabricating a novel cytocompatible hydrogel made of gelatin-alginate as a coating for beta-tricalcium phosphate (β-TCP) scaffolds.

Methods

The hydrogel synthesis was optimized by varying the concentration of the crosslinkers N-hydroxysuccinimide and N-Ethyl-N'-(3-dimethyl aminopropyl) carbodiimide (NHS/EDC). Swelling, degradability and mechanical studies were carried out to identify the suitable hydrogel coating formu

SUBMITTER: Pacelli S 

PROVIDER: S-EPMC6188648 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature