Epidemiology, clinical presentation and respiratory sequelae of adenovirus pneumonia in children in Kuala Lumpur, Malaysia.

ABSTRACT:

Objectives

To describe the severity, human adenovirus (HAdV) type and respiratory morbidity following adenovirus pneumonia in children.

Methodology

Retrospective review of children under 12 years of age, admitted with HAdV pneumonia, between January 2011 and July 2013, in a single centre in Malaysia. HAdV isolated from nasopharyngeal secretions were typed by sequencing hypervariable regions 1-6 of the hexon gene. Patients were reviewed for respiratory complications.

Results

HAdV was detected in 131 children of whom 92 fulfilled inclusion criteria. Median (range) age was 1.1 (0.1-8.0) years with 80% under 2 years. Twenty percent had severe disease with a case-fatality rate of 5.4%. Duration of admission (p = 0.02) was independently associated with severe illness. Twent

SUBMITTER: Li L 

PROVIDER: S-EPMC6188781 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature