Circulating angiogenic stem cells in type 2 diabetes are associated with glycemic control and endothelial dysfunction.

ABSTRACT: Circulating angiogenic cells (CACs) of various described phenotypes participate in the regeneration of the damaged endothelium, but the abundance of these cells is highly influenced by external cues including diabetes. It is not entirely clear which CAC populations are most reflective of endothelial function nor which are impacted by diabetes. To answer these questions, we enrolled a human cohort with variable CVD risk and determined relationships between stratified levels of CACs and indices of diabetes and vascular function. We also determined associations between CAC functional markers and diabetes and identified pro-angiogenic molecules which are impacted by diabetes. We found that subjects with low levels of CD34+/AC133+/CD31+/CD45dim cells (CAC-3) had a significantly higher incidence

SUBMITTER: Zafar N 

PROVIDER: S-EPMC6188890 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature