Positive feedback loop between mitochondrial fission and Notch signaling promotes survivin-mediated survival of TNBC cells.

ABSTRACT: Mitochondrial morphology is remodeled by continuous dynamic cycles of fission and fusion. Emerging data have shown that the disturbance of balance between mitochondrial fission and fusion is involved in the progression of several types of neoplasms. However, the status of mitochondrial dynamics and its potential biological roles in breast cancer (BC), particularly in triple negative BC (TNBC) are not fully clear. Here, we reported that the mitochondrial fission was significantly increased in BC tissues, especially in the TNBC tissues, when compared with that in the corresponding peritumor tissues. Meanwhile, our data showed that Drp1 was upregulated, while Mfn1 was downregulated in TNBC. Moreover, elevated mitochondrial fission was associated with poorer prognosis in TNBC patients. Mitocho

SUBMITTER: Chen L 

PROVIDER: S-EPMC6189045 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature