Inspiratory Lung Expansion in Patients with Interstitial Lung Disease: CT Histogram Analyses.

ABSTRACT: This study aimed to evaluate inspiratory lung expansion in patients with interstitial lung disease (ILD) using histogram analyses based on advanced image registration between inspiratory and expiratory CT scans. We included 16 female ILD patients and eight age- and sex-matched normal controls who underwent full-inspiratory and expiratory CT scans. The CT scans were sequentially aligned based on the surface, landmarks, and attenuation of the lung parenchyma. Histogram analyses were performed on the degree of lung expansion (DLE) of each pixel between the aligned images in x-, y-, z-axes, and 3-dimensionally (3D). The overall mean registration error was 1.9 mm between the CT scans. The DLE_3D in ILD patients was smaller than in the controls (mean, 17.6 mm vs. 26.9 mm; p = 0.023), a

SUBMITTER: Park J 

PROVIDER: S-EPMC6189065 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature