A minority-group of renal cell cancer patients with high infiltration of CD20+B-cells is associated with poor prognosis.

ABSTRACT:

Background

The role of B-lymphocytes in solid tumours is unclear. Tumour biology studies have implied both anti- and pro-tumoural effects and prognostic studies have mainly linked B-cells to increased survival. This study aimed to analyse the clinical relevance of B-lymphocytes in renal cell cancer (RCC), where information on the prognostic impact is lacking.

Methods

Following immunohistochemistry (IHC) stainings with a CD20 antibody, density of CD20+ B-cells was quantified in an RCC discovery- and validation cohort. Associations of B-cell infiltration, determined by CD20 expression or a B-cell gene-signature, and survival was also analysed in 14 publicly available gene expression datasets of cancer, including the kidney clear cell carcinoma (KIRC) dataset.

Results

IH

SUBMITTER: Sjoberg E 

PROVIDER: S-EPMC6189087 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature