Serially measured pre-diagnostic levels of serum cytokines and risk of brain cancer in active component military personnel.

ABSTRACT:

Background

There is growing evidence that history of allergic or autoimmune disease is associated with reduced risk of glioma, but few prospective studies have explored the biological basis. To assess associations with immune conditions and levels of 14 cytokines in serial prediagnostic serum samples, we conducted a study of glioma/brain cancer nested in a cohort of active component military personnel.

Methods

A total of 457 case-control sets were ascertained from the Department of Defense (DoD) Automated Central Tumour Registry, Defense Medical Surveillance System (DMSS) database, and DoD Serum Repository. These were individually matched on sex, race/ethnicity, birth year, number of serum samples (1, 2 or 3), and date(s) of sample collection. We obtained diagnoses of pre-ex

SUBMITTER: Brenner AV 

PROVIDER: S-EPMC6189110 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature