Multi-level genomic analyses suggest new genetic variants involved in human memory.

ABSTRACT: Development of high-throughput genotyping platforms provides an opportunity to identify new genetic elements related to complex cognitive functions. Taking advantage of multi-level genomic analysis, here we studied the genetic basis of human short-term (STM, n = 1623) and long-term (LTM, n = 1522) memory functions. Heritability estimation based on single nucleotide polymorphism showed moderate (61%, standard error 35%) heritability of short-term memory but almost zero heritability of long-term memory. We further performed a two-step genome-wide association study, but failed to find any SNPs that could pass genome-wide significance and survive replication at the same time. However, suggestive significance for rs7011450 was found in the shared component of the two STM tasks. Further inspecti

SUBMITTER: Zhu Z 

PROVIDER: S-EPMC6189113 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature