Hydrogen Sulfide Promotes Bone Homeostasis by Balancing Inflammatory Cytokine Signaling in CBS-Deficient Mice through an Epigenetic Mechanism.

ABSTRACT: Previously, we have shown hyperhomocysteinemia (HHcy) to have a detrimental effect on bone remodeling, which is associated with osteoporosis. During transsulfuration, Hcy is metabolized into hydrogen sulfide (H₂S), a gasotransmitter molecule known to regulate bone formation. Therefore, in the present study, we examined whether H₂S ameliorates HHcy induced epigenetic and molecular alterations leading to osteoporotic bone loss. To test this mechanism, we employed cystathionine-beta-synthase heterozygote knockout mice, fed with a methionine rich diet (CBS^+/- +Met), supplemented with H₂S-donor NaHS for 8 weeks. Treatment with NaHS, normalizes plasma H₂S, and completely prevents trabecular bone loss in CBS^+/- mice. Our data showe

SUBMITTER: Behera J 

PROVIDER: S-EPMC6189133 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature