Inferring biogeographic ancestry with compound markers of slow and fast evolving polymorphisms.

ABSTRACT: Bio-geographic ancestry is an area of considerable interest in the medical genetics, anthropology and forensics. Although genome-wide panels are ideal as they provide dense genotyping data, small sets of ancestry informative marker provide a cost-effective way to investigate genetic ancestry and population structure. Here, we investigate the performance of a reduced marker set that combine different types of autosomal markers through haplotype analysis. In particular, recently described DIP-STR markers should offer the advantage of comprising both, low mutation rate Indels (DIPs), to study human history over longer time scale; and high mutation rate STRs, to trace relatively recent demographic events. In this study, we assessed the ability of an initial set of 23 DIP-STRs to distinguish ma

SUBMITTER: Moriot A 

PROVIDER: S-EPMC6189140 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature