Ovarian tumours of different histologic type and clinical stage induce similar changes in lipid metabolism.

ABSTRACT:

Background

Previous results obtained from serum samples of late-stage, high-grade serous ovarian carcinoma patients showed large alterations in lipid metabolism. To validate and extend the results, we studied lipidomic changes in early-stage ovarian tumours. In addition to serous ovarian cancer, we investigated whether these changes occur in mucinous and endometrioid histological subtypes as well.

Methods

Altogether, 354 serum or plasma samples were collected from three centres, one from Germany and two from Finland. We performed lipidomic analysis of samples from patients with malignant (N = 138) or borderline (N = 25) ovarian tumours, and 191 controls with benign pathology. These results were compared to previously published data.

Results

We found 39 lipids that sho

SUBMITTER: Niemi RJ 

PROVIDER: S-EPMC6189177 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature