Lrig1 marks a population of gastric epithelial cells capable of long-term tissue maintenance and growth in vitro.

ABSTRACT: The processes involved in renewal of the epithelium that lines the mouse stomach remain unclear. Apart from the cells in the isthmus, several other populations located deeper in the gastric glands have been suggested to contribute to the maintenance of the gastric epithelium. Here, we reveal that Lrig1 is expressed in the basal layer of the forestomach and the lower part of glands in the corpus and pylorus. In the glandular epithelium of the stomach, Lrig1 marks a heterogeneous population comprising mainly non-proliferative cells. Yet, fate-mapping experiments using a knock-in mouse line expressing Cre specifically in Lrig1⁺ cells demonstrate that these cells are able to contribute to the long-term maintenance of the gastric epithelium. Moreover, when cultured in vitro, cells ex

SUBMITTER: Schweiger PJ 

PROVIDER: S-EPMC6189208 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature