Characteristics of The Cancer Genome Atlas cases relative to U.S. general population cancer cases.

ABSTRACT:

Background

Despite anecdotal reports of differences in clinical and demographic characteristics of The Cancer Genome Atlas (TCGA) relative to general population cancer cases, differences have not been systematically evaluated.

Methods

Data from 11,160 cases with 33 cancer types were ascertained from TCGA data portal. Corresponding data from the Surveillance, Epidemiology, and End Results (SEER) 18 and North American Association of Central Cancer Registries databases were obtained. Differences in characteristics were compared using Student's t, Chi-square, and Fisher's exact tests. Differences in mean survival months were assessed using restricted mean survival time analysis and generalised linear model.

Results

TCGA cases were 3.9 years (95% CI 1.7-6.2) younger on ave

SUBMITTER: Wang X 

PROVIDER: S-EPMC6189215 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature