Modeling Cerebral Blood Flow Dependence on Carbon Dioxide and Mean Arterial Blood Pressure in the Immature Brain With Accounting for the Germinal Matrix.

ABSTRACT: Intraventricular hemorrhage (IVH) is one of the most critical complications in the development of preterm infants. The likelihood of IVH is strongly associated with disturbances in cerebral blood flow (CBF) and with microvascular fragility in the germinal matrix (GM). The CBF value and its reactivity to changes in arterial carbon dioxide pressure (pCO ₂ ) and mean arterial blood pressure (MABP) are relevant indicators in the clinical assessment of preterm infants. The objective of the present study is mathematical modeling of the influence of pCO ₂ and MABP on CBF in immature brain, based on clinical data collected from 265 preterm infants with 23-30 gestational weeks. The model was ad

SUBMITTER: Sidorenko I 

PROVIDER: S-EPMC6189337 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature