Lipid peroxidation biomarkers for evaluating oxidative stress in equine neuroaxonal dystrophy.

ABSTRACT:

Background

Equine neuroaxonal dystrophy/equine degenerative myeloencephalopathy (eNAD/EDM) is a neurodegenerative disorder affecting genetically predisposed foals maintained on an α-tocopherol (α-TOH) deficient diet. Currently no antemortem diagnostic test for eNAD/EDM is available.

Hypothesis

Because α-TOH deficiency is associated with increased lipid peroxidation, it was hypothesized that F₂ -isoprostanes (F₂ IsoP), F₄ -neuroprostanes (F₄ NP) and oxysterols derived from free radical oxidation would be increased in the cerebrospinal fluid (CSF) and neural tissue of eNAD/EDM affected horses and could serve as potential biomarkers for disease.

Animals

Isoprostane Study A: 14 Quarter horse foals (10 healthy foals and 4 eNAD/ED

SUBMITTER: Finno CJ 

PROVIDER: S-EPMC6189351 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature