Hepatocyte expression and prognostic importance of senescence marker p21 in liver histopathology samples from dogs with chronic hepatitis.

ABSTRACT:

Background

Chronic hepatitis (CH) occurs commonly in dogs but is associated with a variable and largely unpredictable prognosis. p21, a cell-cycle inhibitor and marker of cellular senescence, is upregulated in human liver disease and is a better prognostic marker than histological or clinical scoring systems.

Objective

To quantify hepatocyte p21 immunopositivity in histopathology samples from dogs with CH and determine its association with outcome.

Animals

Twenty-six client-owned dogs with histologically confirmed CH, and 15 dogs with normal liver histology.

Methods

Medical records and liver histopathology samples were retrospectively reviewed to identify cases of CH. Immunohistochemistry for p21 was performed on all samples and hepatocyte immunopositivity was

SUBMITTER: Kortum AJ 

PROVIDER: S-EPMC6189352 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature