Quantitative MRI provides markers of intra-, inter-regional, and age-related differences in young adult cortical microstructure.

ABSTRACT: Measuring the structural composition of the cortex is critical to understanding typical development, yet few investigations in humans have charted markers in vivo that are sensitive to tissue microstructural attributes. Here, we used a well-validated quantitative MR protocol to measure four parameters (R₁, MT, R₂*, PD*) that differ in their sensitivity to facets of the tissue microstructural environment (R₁, MT: myelin, macromolecular content; R₂*: myelin, paramagnetic ions, i.e., iron; PD*: free water content). Mapping these parameters across cortical regions in a young adult cohort (18-39 years, N = 93) revealed expected patterns of increased macromolecular content as well as reduced tissue water content in primary and primary adjacent cortical

SUBMITTER: Carey D 

PROVIDER: S-EPMC6189523 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature