Immunodysfunction in Acute-on-Chronic Liver Failure.

ABSTRACT:

Background

Increasing evidence reveals a close and reciprocal link between acute-on-chronic liver failure (ACLF) and immunodysfunction.

Methods

A literature search in PubMed and abstract databases of relevant congresses was performed.

Results

Important characteristics of liver cirrhosis like tissue hypoxia, cell death, or bacterial translocation maintain a state of chronic inflammation. Precipitating events of ACLF such as infections or alcoholic hepatitis are capable of strongly augmenting cirrhosis-associated systemic inflammation to grades sufficient to induce ACLF-defining organ failures. Chronic systemic inflammation, however, is causally linked to profound immunosuppression. As a consequence, patients with liver cirrhosis and in particular with ACLF are at high

SUBMITTER: Lange CM 

PROVIDER: S-EPMC6189545 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature