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Pharmacokinetics of ?-Lactam Antibiotics: Clues from the Past To Help Discover Long-Acting Oral Drugs in the Future.

ABSTRACT: ?-Lactams represent perhaps the most important class of antibiotics yet discovered. However, despite many years of active research, none of the currently approved drugs in this class combine oral activity with long duration of action. Recent developments suggest that new ?-lactam antibiotics with such a profile would have utility in the treatment of tuberculosis. Consequently, the historical ?-lactam pharmacokinetic data have been compiled and analyzed to identify possible directions and drug discovery strategies aimed toward new ?-lactam antibiotics with this profile.

SUBMITTER: Smith PW

PROVIDER: S-EPMC6189874 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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Pharmacokinetics of β-Lactam Antibiotics: Clues from the Past To Help Discover Long-Acting Oral Drugs in the Future.

Smith Paul W PW Zuccotto Fabio F Bates Robert H RH Martinez-Martinez Maria Santos MS Read Kevin D KD Peet Caroline C Epemolu Ola O

ACS infectious diseases 20180910 10

β-Lactams represent perhaps the most important class of antibiotics yet discovered. However, despite many years of active research, none of the currently approved drugs in this class combine oral activity with long duration of action. Recent developments suggest that new β-lactam antibiotics with such a profile would have utility in the treatment of tuberculosis. Consequently, the historical β-lactam pharmacokinetic data have been compiled and analyzed to identify possible directions and drug di ...[more]

PMID: 30141902

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