An On-Chip RBC Deformability Checker Significantly Improves Velocity-Deformation Correlation.

ABSTRACT: An on-chip deformability checker is proposed to improve the velocity⁻deformation correlation for red blood cell (RBC) evaluation. RBC deformability has been found related to human diseases, and can be evaluated based on RBC velocity through a microfluidic constriction as in conventional approaches. The correlation between transit velocity and amount of deformation provides statistical information of RBC deformability. However, such correlations are usually only moderate, or even weak, in practical evaluations due to limited range of RBC deformation. To solve this issue, we implemented three constrictions of different width in the proposed checker, so that three different deformation regions can be applied to RBCs. By considering cell responses from the three regions as a whole, we practica

SUBMITTER: Tsai CD 

PROVIDER: S-EPMC6190329 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature