Regulation of Sox2 and stemness by nicotine and electronic-cigarettes in non-small cell lung cancer.

ABSTRACT:

Background

Lung cancer is the leading cause of cancer related deaths and its incidence is highly correlated with cigarette smoking. Nicotine, the addictive component of tobacco smoke, cannot initiate tumors, but can promote proliferation, migration, and invasion of cells in vitro and promote tumor growth and metastasis in vivo. This nicotine-mediated tumor promotion is facilitated through the activation of nicotinic acetylcholine receptors (nAChRs), specifically the α7 subunit. More recently, nicotine has been implicated in promoting self-renewal of stem-like side-population cells from lung cancers. This subpopulation of cancer stem-like cells has been implicated in tumor initiation, generation of the heterogeneous tumor population, metastasis, dormancy, and drug resistance. Here w

SUBMITTER: Schaal CM 

PROVIDER: S-EPMC6190543 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature