KRAS mutation in secondary malignant histiocytosis arising from low grade follicular lymphoma.

ABSTRACT:

Background

Transformation of follicular lymphoma most typically occurs as diffuse large B-cell lymphoma, however other forms of transformation such as classic Hodgkin lymphoma and lymphoblastic transformation can occur. Secondary malignant histiocytosis also represents a rare form of transformation, which is thought to occur due to a process of transdifferentiation whereby the lymphoma cells exhibit lineage plasticity and lose all evidence of B-cell phenotype and instead acquire the phenotype of a histiocytic neoplasm. Little is known about the underlying genetic alterations that occur during this unusual process. Comparative genetic analysis of pre- and post-transformation/transdifferentiation would be one tool by which we could better understand how this phenomenon occurs.

Cas

SUBMITTER: Choi SM 

PROVIDER: S-EPMC6190545 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature