P3H4 is correlated with clinicopathological features and prognosis in bladder cancer.

ABSTRACT:

Background

Genetic alterations play a significant role in the progression of bladder cancer. Identifying novel biomarkers to personalize the therapeutic regimen and evaluate the prognosis of patients with bladder cancer is vital. Prolyl 3-hydroxylase family member 4 (P3H4) is significantly involved in several types of human cancer. However, the effect of P3H4 in bladder cancer remains unknown.

Methods

The mRNA expression of P3H4 was measured in 44 paired tumors and adjacent normal tissues by using real-time reverse transcription-polymerase chain reaction. RNA-Seq data of 389 patients with bladder cancer were downloaded to investigate the effect of P3H4 on bladder cancer from The Cancer Genome Atlas (TCGA) project.

Results

P3H4 was overexpressed in bladder cancer compa

SUBMITTER: Li W 

PROVIDER: S-EPMC6190559 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature