Modulation of astrocyte reactivity improves functional deficits in mouse models of Alzheimer's disease.

ABSTRACT: Astrocyte reactivity and neuroinflammation are hallmarks of CNS pathological conditions such as Alzheimer's disease. However, the specific role of reactive astrocytes is still debated. This controversy may stem from the fact that most strategies used to modulate astrocyte reactivity and explore its contribution to disease outcomes have only limited specificity. Moreover, reactive astrocytes are now emerging as heterogeneous cells and all types of astrocyte reactivity may not be controlled efficiently by such strategies.Here, we used cell type-specific approaches in vivo and identified the JAK2-STAT3 pathway, as necessary and sufficient for the induction and maintenance of astrocyte reactivity. Modulation of this cascade by viral gene transfer in mouse astrocytes efficiently controlled seve

SUBMITTER: Ceyzeriat K 

PROVIDER: S-EPMC6190663 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature