Trajectories of changes in glucose tolerance in a multiethnic cohort of obese youths: an observational prospective analysis.

ABSTRACT:

Background

Type 2 diabetes is preceded by a prediabetic stage of impaired glucose tolerance that affects 10-23% of youth and is expected to double over the next decade. The natural history of impaired glucose tolerance and the determinants of β-cell dynamic response have never been investigated longitudinally in young people. We aimed to investigate the clinical and metabolic determinants of longitudinal glucose tolerance changes and β-cell function in a multiethnic cohort of obese youth.

Methods

We followed up prospectively a multiethnic cohort of overweight and obese (body-mass index >85th percentile) adolescents with baseline normal glucose tolerance (plasma glucose <140 mg/dL) or impaired glucose tolerance (plasma glucose 140-199 mg/dL) at the Yale Pediatric Obesity Clin

SUBMITTER: Galderisi A 

PROVIDER: S-EPMC6190831 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature