Gastrectomy with Roux-en-Y reconstruction as a lean model of bariatric surgery.

ABSTRACT:

Background

Altered enteroendocrine hormone responses are widely believed to underlie the beneficial effects of bariatric surgery in type 2 diabetes. While elevated postprandial glucagon-like peptide-1 (GLP-1) is considered one of the mediators, increased postprandial glucagon levels have recently been implicated.

Objectives

We investigated hormonal responses in lean patients after prophylactic total gastrectomy (PTG), as a model of Roux-en-Y gastric bypass without the confounding effects of obesity or massive weight loss.

Setting

University hospital, United Kingdom.

Methods

Ten participants after PTG and 9 healthy volunteers were recruited for oral glucose tolerance tests. Plasma glucose, insulin, GLP-1, peptide YY, glucose-dependent insulinotropic-polypeptide,

SUBMITTER: Roberts GP 

PROVIDER: S-EPMC6191023 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature