A genomic ruler to assess oncogenic transition between breast tumor and stroma.

ABSTRACT:

Background

Cancers induce gene expression alterations in stroma surrounding tumors that supports cancer progression. However, it is actually not at all known the extent of altered stromal gene expression enacted by tumors nor the extent to which altered stromal gene expression penetrates the stromal tissue. Presently, post-surgical "tumor-free" stromal tissue is determined to be cancer-free based on solely on morphological normality-a criteria that has not changed in more than 100 years despite the existence of sophisticated gene expression data to the contrary. We therefore investigated the extent to which breast tumors alter stromal gene expression in three dimensions in women undergoing mastectomy with the intent of providing a genomic determination for development of future ris

SUBMITTER: Dhage S 

PROVIDER: S-EPMC6191134 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature