Individual susceptibility to arsenic-induced diseases: the role of host genetics, nutritional status, and the gut microbiome.

ABSTRACT: Arsenic (As) contamination in water or food is a global issue affecting hundreds of millions of people. Although As is classified as a group 1 carcinogen and is associated with multiple diseases, the individual susceptibility to As-related diseases is highly variable, such that a proportion of people exposed to As have higher risks of developing related disorders. Many factors have been found to be associated with As susceptibility. One of the main sources of the variability found in As susceptibility is the variation in the host genome, namely, polymorphisms of many genes involved in As transportation, biotransformation, oxidative stress response, and DNA repair affect the susceptibility of an individual to As toxicity and then influence the disease outcomes. In addition, lifestyles and m

SUBMITTER: Chi L 

PROVIDER: S-EPMC6191311 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature