Identification and characterization of two novel alternatively spliced E2F1 transcripts in the rat CNS.

ABSTRACT: E2F1 is a transcription factor classically known to regulate G₀/G₁ to S phase progression in the cell cycle. In addition, E2F1 also regulates a wide range of apoptotic genes and thus has been well studied in the context of neuronal death and neurodegenerative diseases. However, its function and regulation in the mature central nervous system are not well understood. Alternative splicing is a well-conserved post-transcriptional mechanism common in cells of the CNS and is necessary to generate diverse functional modifications to RNA or protein products from genes. Heretofore, physiologically significant alternatively spliced E2F1 transcripts have not been reported. In the present study, we report the identification of two novel alternatively spliced E2F1 transcripts: E2

SUBMITTER: Jackson DP 

PROVIDER: S-EPMC6191325 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature