Defining and Predicting Early Recurrence in 957 Patients With Resected Pancreatic Ductal Adenocarcinoma.

ABSTRACT:

Objectives

To establish an evidence-based cut-off to differentiate between early and late recurrence and to compare clinicopathologic risk factors between the two groups.

Summary background data

A clear definition of "early recurrence" after pancreatic ductal adenocarcinoma resection is currently lacking.

Methods

Patients undergoing pancreatectomy for pancreatic ductal adenocarcinoma between 2000 and 2013 were included. Exclusion criteria were neoadjuvant therapy and incomplete follow-up. A minimum P-value approach was used to evaluate the optimal cut-off value of recurrence-free survival to divide the patients into early and late recurrence cohorts based on subsequent prognosis. Potential risk factors for early recurrence were assessed with logistic regression models

SUBMITTER: Groot VP 

PROVIDER: S-EPMC6191366 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature