TDP-43 pathology in multiple system atrophy: colocalization of TDP-43 and α-synuclein in glial cytoplasmic inclusions.

ABSTRACT:

Aims

This study aimed to assess clinicopathologic features of transactive response DNA-binding protein of 43 kDa (TDP-43) pathology and its risk factors in multiple system atrophy (MSA).

Methods

Paraffin-embedded sections of the amygdala and basal forebrain from 186 autopsy-confirmed MSA cases were screened with immunohistochemistry for phospho-TDP-43. In cases having TDP-43 pathology, additional brain regions were assessed. Immunohistochemical and immunofluorescence double-staining and immunogold electron microscopy (IEM) were performed to evaluate colocalization of TDP-43 and α-synuclein. Genetic risk factors for TDP-43 pathology were also analysed.

Results

Immunohistochemistry showed various morphologies of TDP-43 pathology in 13 cases (7%), such as subpial astrocy

SUBMITTER: Koga S 

PROVIDER: S-EPMC6191374 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature