Polygenic risk for psychiatric disorders correlates with executive function in typical development.

ABSTRACT: Executive functions are a diverse and critical suite of cognitive abilities that are often disrupted in individuals with psychiatric disorders. Despite their moderate to high heritability, little is known about the molecular genetic factors that contribute to variability in executive functions and how these factors may be related to those that predispose to psychiatric disorders. We examined the relationship between polygenic risk scores built from large genome-wide association studies of psychiatric disorders and executive functioning in typically developing children. In our discovery sample (N = 417), consistent with previous reports on general cognitive abilities, polygenic risk for autism spectrum disorder was associated with better performance on the Dimensional Change Card Sort test

SUBMITTER: Schork AJ 

PROVIDER: S-EPMC6191376 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature