Feature selectivity is stable in primary visual cortex across a range of spatial frequencies.

ABSTRACT: Reliable perception of environmental signals is a critical first step to generating appropriate responses and actions in awake behaving animals. The extent to which stimulus features are stably represented at the level of individual neurons is not well understood. To address this issue, we investigated the persistence of stimulus response tuning over the course of 1-2 weeks in the primary visual cortex of awake, adult mice. Using 2-photon calcium imaging, we directly compared tuning stability to two stimulus features (orientation and spatial frequency) within the same neurons, specifically in layer 2/3 excitatory neurons. The majority of neurons that were tracked and tuned on consecutive imaging sessions maintained stable orientation and spatial frequency preferences (83% and 76% of the po

SUBMITTER: Jeon BB 

PROVIDER: S-EPMC6191427 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature