Ontology highlight
ABSTRACT:
SUBMITTER: Diogo D
PROVIDER: S-EPMC6191429 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Nature communications 20181016 1
Phenome-wide association studies (PheWAS) have been proposed as a possible aid in drug development through elucidating mechanisms of action, identifying alternative indications, or predicting adverse drug events (ADEs). Here, we select 25 single nucleotide polymorphisms (SNPs) linked through genome-wide association studies (GWAS) to 19 candidate drug targets for common disease indications. We interrogate these SNPs by PheWAS in four large cohorts with extensive health information (23andMe, UK Bi ...[more]