The Volume of Hippocampal Subfields in Relation to Decline of Memory Recall Across the Adult Lifespan.

ABSTRACT: Background: The hippocampus is an important limbic structure closely related to memory function. However, few studies have focused on the association between hippocampal subfields and age-related memory decline. We investigated the volume alterations of hippocampal subfields at different ages and assessed the correlations with Immediate and Delayed recall abilities. Materials and Methods: A total of 275 participants aged 20-89 years were classified into 4 groups: Young, 20-35 years; Middle-early, 36-50 years; Middle-late, 51-65 years; Old, 66-89 years. All data were acquired from the Dallas Lifespan Brain Study (DLBS). The volumes of hippocampal subfields were obtained using Freesurfer software. Analysis of covariance (ANCOVA) was performed to analyze alterations of subfield

SUBMITTER: Zheng F 

PROVIDER: S-EPMC6191512 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature