Real-time cancer detection with an integrated lensless fluorescence contact imager.

ABSTRACT: Microscopic tumor cell foci left in a patient after surgery significantly increase the chance of cancer recurrence. However, fluorescence microscopes used for intraoperative navigation lack the necessary sensitivity for imaging microscopic disease and are too bulky to maneuver within the resection cavity. We have developed a scalable chip-scale fluorescence contact imager for detecting microscopic cancer in vivo and in real-time. The imager has been characterized under simulated in vivo conditions using ex vivo samples, providing strong evidence that our device can be used in vivo. Angle-selective gratings enhance the resolution of the imager without impacting its physical size. We demonstrate detection of cancer cell clusters containing as few as 25 HCC1569 bre

SUBMITTER: Papageorgiou EP 

PROVIDER: S-EPMC6191610 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature