Owl monkey CCR5 reveals synergism between CD4 and CCR5 in HIV-1 entry.

ABSTRACT: Studying HIV-1 replication in the presence of functionally related proteins from different species has helped define host determinants of HIV-1 infection. Humans and owl monkeys, but not macaques, encode a CD4 receptor that permits entry of transmissible HIV-1 variants due to a single residue difference. However, little is known about whether divergent CCR5 receptor proteins act as determinants of host-range. Here we show that both owl monkey (Aotus vociferans) CD4 and CCR5 receptors are functional for the entry of transmitted HIV-1 when paired with human versions of the other receptor. By contrast, the owl monkey CD4/CCR5 pair is generally a suboptimal receptor combination, although there is virus-specific variation in infection with owl monkey receptors. Introduction of the human residue

SUBMITTER: Nahabedian J 

PROVIDER: S-EPMC6191650 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature