Serial circulating omega 3 polyunsaturated fatty acids and healthy ageing among older adults in the Cardiovascular Health Study: prospective cohort study.

ABSTRACT:

Objective

To determine the longitudinal association between serial biomarker measures of circulating omega 3 polyunsaturated fatty acid (n3-PUFA) levels and healthy ageing.

Design

Prospective cohort study.

Setting

Four communities in the United States (Cardiovascular Health Study) from 1992 to 2015.

Participants

2622 adults with a mean (SD) age of 74.4 (4.8) and with successful healthy ageing at baseline in 1992-93.

Exposure

Cumulative levels of plasma phospholipid n3-PUFAs were measured using gas chromatography in 1992-93, 1998-99, and 2005-06, expressed as percentage of total fatty acids, including α-linolenic acid from plants and eicosapentaenoic acid, docosapentaenoic acid, and docosahexaenoic acid from seafoood.

Main outcome measure

Healthy a

SUBMITTER: Lai HT 

PROVIDER: S-EPMC6191654 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature