Pre-eclampsia and risk of dementia later in life: nationwide cohort study.

ABSTRACT:

Objective

To explore associations between pre-eclampsia and later dementia, overall and by dementia subtype and timing of onset.

Design

Nationwide register based cohort study.

Setting

Denmark.

Population

All women with at least one live birth or stillbirth between 1978 and 2015.

Main outcome measure

Hazard ratios comparing dementia rates among women with and without a history of pre-eclampsia, estimated using Cox regression.

Results

The cohort consisted of 1 178 005 women with 20 352 695 person years of follow-up. Women with a history of pre-eclampsia had more than three times the risk of vascular dementia (hazard ratio 3.46, 95% confidence interval 1.97 to 6.10) later in life, compared with women with no history of pre-eclampsia. The association

SUBMITTER: Basit S 

PROVIDER: S-EPMC6191824 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature