TRPV2-induced Ca²⁺-calcineurin-NFAT signaling regulates differentiation of osteoclast in multiple myeloma.

ABSTRACT:

Background

Myeloma bone disease (MBD) can cause bone destruction and increase the level of Ca²⁺ concentration in the bone marrow microenvironment by stimulating osteoclastic differentiation. Nevertheless, the relationships between MBD and highly efficient stimuli of Ca²⁺ in multiple myeloma (MM) progression, and possible regulatory mechanisms are poorly defined. Here, we reported that the nonselective cation channel transient receptor potential vanilloid 2 (TRPV2) plays a functional role in Ca²⁺ oscillations and osteoclastogenesis.

Methods

To investigate the expression of TRPV2 in MM, we analyzed publicly available MM data sets and performed immunohistochemistry in MM patients. The correlations between TRPV2 expression levels and osteoclast-r

SUBMITTER: Bai H 

PROVIDER: S-EPMC6191893 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature