Mitochondrial DNA 7908-8816 region mutations in maternally inherited essential hypertensive subjects in China.

ABSTRACT:

Background

Nuclear genes or family-based mitochondrial screening have been the focus of genetic studies into essential hypertension. Studies into the role of mitochondria in sporadic Chinese hypertensives are lacking. The objective of the study was to explore the relationship between mitochondrial DNA (mtDNA) variations and the development of maternally inherited essential hypertension (MIEH) in China.

Methods

Yangzhou residents who were outpatients or in-patients at the Department of Cardiology in Northern Jiangsu People's Hospital (Jiangsu, China) from June 2009 to June 2015 were recruited in a 1:1 case control study of 600 gender-matched Chinese MIEH subjects and controls. Genomic DNA was isolated from whole blood cells. The most likely sites for hypertension were screene

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC6191914 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature