Accuracy Improvement of In-line Near-Infrared Spectroscopic Moisture Monitoring in a Fluidized Bed Drying Process.

ABSTRACT: An exploratory analysis of a large representative dataset obtained in a fluidized bed drying process of a pharmaceutical powder has revealed a significant correlation of spectral intensity with granulate humidity in the whole studied range of 1091.8-2106.5 nm. This effect was explained by the dependence of powder refractive properties, and hence light penetration depth, on the water content. The phenomenon exhibited a close spectral similarity to the well-known stochastic variation of spectral intensities caused by the process turbulence (the so-called "scatter effect"). Therefore, any traditional scatter-corrective preprocessing incidentally eliminates moisture-correlated variance from the data. To preserve this additional information for a more precise moisture calibration, a time-domain

SUBMITTER: Bogomolov A 

PROVIDER: S-EPMC6192013 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature