Direct arylation of strong aliphatic C-H bonds.

ABSTRACT: Despite the widespread success of transition-metal-catalysed cross-coupling methodologies, considerable limitations still exist in reactions at sp³-hybridized carbon atoms, with most approaches relying on prefunctionalized alkylmetal or bromide coupling partners^1,2. Although the use of native functional groups (for example, carboxylic acids, alkenes and alcohols) has improved the overall efficiency of such transformations by expanding the range of potential feedstocks^3-5, the direct functionalization of carbon-hydrogen (C-H) bonds-the most abundant moiety in organic molecules-represents a more ideal approach to molecular construction. In recent years, an impressive range of reactions that form C(sp³)-heteroatom bonds from strong C-H bonds has bee

SUBMITTER: Perry IB 

PROVIDER: S-EPMC6192026 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature