Acanthus ebracteatus leaf extract provides neuronal cell protection against oxidative stress injury induced by glutamate.

ABSTRACT:

Background

Acanthus ebracteatus (AE), an herb native to Asia, has been recognized in traditional folk medicine not only for its antioxidant properties and various pharmacological activities but also as an ingredient of longevity formulas. However, its anti-neurodegenerative potential is not yet clearly known. This work aimed to evaluate the protective effect of AE leaf extract against glutamate-induced oxidative damage in mouse hippocampal HT22 cells, a neurodegenerative model system due to a reduction in glutathione levels and an increase in reactive oxygen species (ROS).

Methods

Cell viability, apoptosis, and ROS assays were performed to assess the protective effect of AE leaf extract against glutamate-induced oxidative toxicity in HT22 cells. The antioxidant capacity of A

SUBMITTER: Prasansuklab A 

PROVIDER: S-EPMC6192065 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature